RAF Typhoon jets have operated alongside French aircraft in a joint strike targeting an underground arms cache in Syria used by the IS group, as stated by the UK's MoD.
The site, identified by surveillance, was assessed as containing munitions and bombs, the announcement noted, and was positioned in hills just above Palmyra in Syria's central region.
"Our fighter planes used precision-guided Paveway IV munitions to strike a series of entry passages down to the depot... preliminary assessments indicate the target was engaged successfully," the ministry announced.
There was no sign of any civilian impact in the strike conducted Saturday night and every plane involved made a safe return, the ministry further stated.
The British jets were assisted by a Voyager aerial refuelling aircraft.
Daesh - referred to as the so-called Islamic State - established jihadist rule over significant areas in Syria and Iraq prior to its 2019 collapse.
"This action demonstrates the UK's leading role, and resolve to work closely with our allies, to stamp out any revival of Daesh and their harmful and extremist ideologies in the Middle East," UK Defence Secretary the minister said.
British military aircraft have carried out patrols over Syrian airspace to "prevent any efforts to regroup" of IS after its defeat at the battle of Baghuz in the year 2019, the authorities noted.
"I must thank the personnel of our armed forces involved in this operation for their expertise and their valour," he said. "They were among numerous British personnel on duty over the holidays. This action, to take out dangerous terrorists who endanger our way of life, highlights how British military are always on standby, throughout the year, protecting the UK domestically and strong abroad."
During December, the American forces conducted what it described as a "large-scale strike" on Islamic State objectives in Syria, following an assault killed two US servicemembers and a civilian interpreter in the Palmyra area.
The UN reports IS still maintains an estimated 5,000 to 7,000 fighters in Iraq and Syria.